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--- url: https://avea-life.com/products/skinspan title: Unknown scraped_at: 2025-11-29 type: shopify ---  4.8/5 based on over 800 ratings ### SkinSpan™ SkinSpan™ combines clinically studied active ingredients which reinforce the skin barrier and boost deep hydration, promote cellular renewal and protect against oxidative stress – thus helping your skin stay firm, smooth, and resilient over time. While popular skin supplements focus on replenishing lost collagen, we designed SkinSpan™ in collaboration with longevity researchers in Switzerland to support your skin’s ability to hydrate, repair, and renew itself from within, before visible signs of collagen decline appear. Its synergistic formula: - Strengthens the skin barrier and restores deep hydration - Promotes healthy skin cell vitality and skin cell renewal - Defends against visible signs of collagen loss, helping smooth fine lines and improve elasticity - Protects against oxidative stress, a key factor in premature ageing Support your skin barrier before collagen loss begins. As we age, our skin’s natural renewal process begins to slow. Barrier function weakens, moisture loss increases, and the effects of oxidative stress and inflammation become more visible – long before collagen breakdown is fully underway. We designed SkinSpan™ to go beyond hydration or plumping – supporting the skin’s natural defences, restoring moisture loss, reducing oxidative damage, and improving the skin’s ability to renew – even before collagen breakdown becomes visible. - Skin Barrier & Hydration Support SkinSpan™ combines 200 mg of high-molecular weight hyaluronic acid with Ceramosides™, a patented complex of plant-derived ceramides, to deliver intensive hydration while strengthening the skin’s protective barrier. This dual-action approach helps visibly plump and smooth the skin, reduce transepidermal water loss¹, and significantly improve wrinkles and dryness². - Firmness & Collagen Support While our Collagen Activator provides the key building blocks for our bodies to produce collagen, SkinSpan™ further enhances firmness, tone, and overall skin density by supporting collagen production and integrity. It combines DracoBelle™ Nu, a flower extract, which enhances collagen production⁴ with essential collagen co-factors like copper and Vitamin C, as well as Ceramosides™ to work together to support collagen integrity and help maintain a youthful skin texture. - Cellular Renewal & Skin Longevity SkinSpan™ is powered by PhytoCellTec™ Md Nu, a clinically studied plant stem cell extract shown to support skin stem cell vitality and accelerate the renewal of skin cells³. As the skin’s natural renewal cycle slows with age – from around 28 days to over 80 – this ingredient supports a more youthful turnover cycle, improving texture, tone, and overall skin vitality. - Skin Cell Protection With powerful antioxidants like beta-carotene and DracoBelle™ Nu, Skinspan™ forms a protective shield against oxidative stress caused by sun exposure, pollution, and daily environmental stressors. By effectively defending skin cells, it reduces visible signs of ageing and keeps your skin looking stronger, smoother, and more radiant. ## Understanding skin ageing beyond collagen: why your skin barrier matters in skin longevity #### Skin Health basics Most conversations around skin ageing start and end with collagen. But while collagen loss is an important part of the picture, it’s also not the whole story. Beneath the surface lies the true foundation of skin health: your skin barrier. This ultra-thin, yet highly sophisticated layer of lipids, ceramides, and tightly packed skin cells is responsible for more than just glow – it regulates hydration, protects against irritants, and supports resilience on a cellular level. When functioning well, the skin barrier helps you retain moisture, defend against environmental stressors, and maintain a smooth, even complexion. As we age, however, this barrier becomes more fragile. Ageing triggers a series of biological shifts that weaken the skin’s structural integrity – slowing cellular renewal, reducing the production of lipids, ceramides, and hyaluronic acid, and accelerating collagen breakdown, thus leading to dryness, dullness, fine lines, and greater sensitivity. These changes often begin before visible collagen loss occurs – and compromise the skin’s ability to hydrate, renew, and protect itself from within. - Why hyaluronic acid is essential for supporting the skin barrier, but not enough on its own Hyaluronic acid (HA) is a naturally occurring molecule found throughout the body, and best known for its remarkable ability to hold up to 1,000 times its weight in water. In the skin, HA fills the space between collagen and elastin fibres, keeping it firm, supple, and hydrated. As a core structural molecule, it plays a critical role in: - Hydration and elasticity - Tissue regeneration and wound repair - Joint lubrication and shock absorption - Nutrient transport and cellular signalling However, the body’s natural production of hyaluronic acid declines with age, thus leading to visible signs of ageing such as dryness, fine lines, and loss of volume, as well as deeper structural weakness and reduced skin recovery. Many turn to topical HA products as a result, and while these can offer temporary surface-level hydration, oral HA supplementation has been shown to be more effective at restoring deeper moisture and skin density from within. Clinical studies show that ingestible HA can significantly improve skin smoothness, elasticity, and hydration over time. It’s important to note, however, that while hyaluronic acid provides powerful support for hydration and tissue health, **it’s not enough on its own to visibly improve skin structure.** The skin is a complex, multi-layered organ, made not only of water-attracting molecules like HA, but also of lipids, proteins, and actively regenerating cells. Simply increasing water content won’t rebuild what time, stress, and oxidative damage break down. To truly repair and renew, your skin also needs: - Ceramides to seal in moisture and reinforce the skin barrier - Botanical compounds and nutrients that promote healthy cell renewal - Collagen support to restore firmness and elasticity from within - Antioxidants to neutralise oxidative stress that breaks down collagen and elastin Think of hyaluronic acid as a sponge: it draws in moisture, but without the barrier strength and regenerative support to hold it in, that moisture is quickly lost. Even the most advanced HA supplement cannot rebuild the skin on its own. - How SkinSpan™ works – and how it’s different from other skincare solutions We designed SkinSpan™ in collaboration with longevity researchers in Switzerland to support your skin’s ability to hydrate, repair, and renew itself from within, before visible signs of collagen decline appear. Unlike traditional beauty blends, SkinSpan™ was designed with synergistic ingredients to work across multiple biological pathways: **For Skin Barrier Strength & Lasting Hydration:** The skin barrier is your first line of defence, but with age, it becomes thinner, more fragile, and less effective at retaining moisture or protecting against daily stressors. SkinSpan™ helps fortify this critical structure with **Ceramosides** ™, a patented complex of plant-derived ceramides that strengthens the skin barrier and locks moisture in. To complement this, **200mg of high molecular weight Hyaluronic Acid** delivers deep hydration, restoring suppleness from within. This dual approach helps restore plumpness, reduce transepidermal water loss, and reinforce resilience against dryness and irritation. **For Deep Cellular Renewal**: SkinSpan™ is powered by **PhytoCellTec** ™ **Md Nu**, a clinically studied plant stem cell extract that helps restore skin stem cell vitality and accelerate epidermal regeneration. As the skin’s natural renewal cycle slows with age – from around 28 days to over 80 – this ingredient supports a more youthful turnover cycle, improving texture, tone, and overall skin vitality. To further enhance renewal, SkinSpan™ includes **Beta-Carotene**, a natural precursor of Vitamin A. Once converted in the body, it gently stimulates cell turnover, encouraging the shedding of dull, older cells and revealing fresher, clearer skin beneath. **For Collagen Support:** While our [Collagen Activator](https://avea-life.com/products/collagen-activator) provides the key building blocks for our bodies to produce collagen, **SkinSpan** ™ complements this by enhancing the skin’s ability to maintain firmness, tone, and structural integrity. It features a synergistic blend of **DracoBelle** ™ **Nu** (a longevity flower extract that supports endogenous collagen production), **Vitamin C**, and **Copper**, key cofactors that stimulate collagen synthesis and help protect skin cells from oxidative stress. **For Skin Cell Protection**: SkinSpan™ helps defend against one of the most overlooked drivers of skin ageing: oxidative stress. Featuring **Beta-Carotene** and **DracoBelle** ™ **Nu**, it provides targeted antioxidant support to help neutralise free radicals triggered by UV exposure, pollution, and everyday stressors. This protection helps preserve cellular integrity, reduce premature signs of ageing, and maintain a smoother, more radiant complexion over time. The result of SkinSpan™ is a science-driven formula that doesn’t just add moisture – it enhances your skin’s _own_ regenerative intelligence. Unlike conventional blends that focus on superficial hydration or isolated ingredients, every ingredient within SkinSpan™ has been carefully selected, precisely dosed, and clinically supported to work in synergy, thus promoting visible improvements in firmness, smoothness, and skin resilience over time. - How does SkinSpan™ work differently from AVEA’s Collagen Activator? Collagen is essential for skin firmness, elasticity, and structural integrity – but boosting collagen alone isn’t the full picture. **Our** [**Collagen Activator**](https://avea-life.com/products/collagen-activator) is designed to _stimulate collagen production directly_ at the source using Colgevity™, a patented, vegan collagen precursor clinically shown to be up to 4x more effective than standard peptides. It focuses on rebuilding the skin’s internal scaffolding by supplying the _signals and cofactors_ your cells need to create new collagen. **SkinSpan** ™, on the other hand, addresses _what causes collagen to break down in the first place_. It supports the _skin barrier_, replenishes lost hydration, and enhances _cellular renewal_ – creating the optimal environment for your skin to preserve and protect its existing collagen and respond more effectively to collagen-boosting interventions. In other words: - **Collagen Activator = collagen production** - **SkinSpan** ™ **= collagen preservation + barrier repair + skin cell renewal** Used together, they offer a **comprehensive approach to skin longevity** – stimulating collagen from within _and_ protecting the structures that keep it intact. ## Clinical studies on SkinSpan™ ingredients show: ## 53.6% increased hydration after 2 months (DracoBelle™ Nu)¹ ## 81% noticed that their skin felt smoother (PhytoCellTec™ Md Nu)² ## 8.7% increase in dermis thickness(DracoBelle™ Nu)¹ ## 14 days to better skin quality & reduced wrinkle depth (Ceramosides™)³ _¹ Baumann et al., OBM Geriatrics, 2025_ _² Baumann et al., J. Food Nutr. Diet Sci., 2024_ _³ Kern et al., J. Cosmet. Dermatol., 2024_ New # SkinSpan™ 30 capsules per bottle Developed with longevity researchers in Switzerland, SkinSpan™ is formulated to reinforce the skin barrier, boost cellular renewal, restore deep hydration, and protect against oxidative stress – helping your skin stay firm, smooth, and resilient over time. While popular skin supplements focus on replenishing lost collagen, SkinSpan™​supports your skin’s natural defences against decline by enhancing its own regenerative abilities – resulting in visibly smoother, firmer, and more resilient skin. It works across multiple pathways with clinically studied ingredients: - **Hyaluronic Acid** ( **200 mg)** and **Ceramosides** ™ **(30 mg)** replenish deep hydration and strengthen the skin barrier - **PhytoCellTec** ™ **Md Nu** (10 mg) supports skin stem cell vitality and promotes healthy skin cell turnover - **Vitamin C** (80 mg), Copper (1 mg) and **DracoBelle** ™ **Nu**(200 mg) contribute to natural collagen formation, helping smooth fine lines and improve elasticity - **Antioxidants** like Beta Carotene (4.8 mg) and Niacin (16mg) help protect against oxidative stress, a key factor in premature ageing Together, these ingredients help to protect and reinforce the skin’s structure, restore lasting hydration, and defend against early collagen breakdown – supporting skin that stays firm, supple, and radiant over time. Subscribe & Save $69.30$2.31 / serving Save up to 25% Annual Save 25% BEST VALUE Quarterly Save 15% MOST POPULAR Monthly Save 10% 1-month supply delivered monthly Pause or cancel at any time One Time Purchase $77.00$2.57 / serving 1 Unit 3 Units Save 5% 6 Units Save 10% MOST POPULAR 12 Units Save 15% BEST VALUE Add to Cart$69.30 90 days money-back guarantee ### FREE Collagen (€79 value) with every order Receive our best-selling, patented Raspberry Mint Collagen Activator for free with every order this Black Friday, only while stocks last. Daily intake guide Take one capsule per day with food. * * * Supplement Facts Manufactured in Switzerland Formulated by Experts Tested by 3rd Parties Sustainable Packaging Clinically proven results Halal Vegan Active ingredients: Hyaluronic Acid 200 mg, Moldavian Dragonhead Extract (DracoBelle™ Nu) 200 mg, Vitamin C 80 mg, Wheat Seed Extract (Ceramosides™) 30 mg, Niacin (Vitamin B3) 16 mg, PhytoCellTecTM Md Nu 10 mg corresponds to Apple Fruit Cell Culture Biomass 0.15 mg, Beta Carotene  4.8 mg corresponds to Vitamin A 800 μg RE, Riboflavin (Vitamin B2) 1.4 mg, Copper 1 mg, Biotin 50 μg Other ingredients - Microcrystalline cellulose as bulking agent to ensure the capsule is completely full (active ingredients may not take up enough space), aiding in consistent manufacturing and dosing - Magnesium salts of fatty acids as anti-caking agent to ensure that powdered contents remain free-flowing (important for manufacturing) and to help achieve a consistent mixture of ingredients within the capsule (ensuring proper dosage) - Hydroxypropyl methyl cellulose (HPMC) as glazing agent in form of a vegetable capsule shell * * * Benefit references Our formulations are based on cutting-edge Longevity research. Led by Chief Science Officer Sophie Chabloz, our team collaborates with longevity experts from top institutions to create highly effective, science-backed products. | Ingredients | Benefits | | --- | --- | --- | --- | | Supports healthy skin barrier and hydration | Promotes healthy skin firmness and collagen production | Supports healthy skin cell turnover and vitality | Promotes healthy skin cell function and maintenance | | Hyaluronic Acid | [Hsu et al., 2021](https://pubmed.ncbi.nlm.nih.gov/34203487/)<br>[Oe et al., 2017](https://pubmed.ncbi.nlm.nih.gov/28761365/) | [Hsu et al., 2021](https://pubmed.ncbi.nlm.nih.gov/34203487/)<br>[Oe et al., 2017](https://pubmed.ncbi.nlm.nih.gov/28761365/) | | | | Moldavian Dragonhead Extract (DracoBelle™ Nu) | [Baumann et al., 2025](https://www.lidsen.com/journals/geriatrics/geriatrics-09-02-305)<br>[Wandrey et al., 2021](https://acquaintpublications.com/article/evaluation_of_the_collagen_boosting_effects_of_a_moldavian_dragonhead_extract) | [Wandrey et al., 2021](https://acquaintpublications.com/article/evaluation_of_the_collagen_boosting_effects_of_a_moldavian_dragonhead_extract) | | | | Wheat Seed Extract (Ceramosides™) | [Bizot et al., 2017](https://www.mdpi.com/2079-9284/4/4/37)<br>[Kern et al., 2024](https://pubmed.ncbi.nlm.nih.gov/38100124/) | | | | | PhytoCellTec™ Md Nu (Apple Fruit Cell Culture Biomass) | [Baumann et al., 2024](https://ojs.luminescience.cn/FNDS/article/view/237) | | [Baumann et al., 2024](https://ojs.luminescience.cn/FNDS/article/view/237) | | | Beta Carotene (as source of Vitamin A) | | | | [EFSA Journal 2010;8(10):1754](http://www.efsa.europa.eu/en/efsajournal/doc/1754.pdf) | | Vitamin C | | [EFSA Journal 2009;7(9):1226](http://www.efsa.europa.eu/en/efsajournal/doc/1226.pdf) | | [EFSA Journal 2010;8(10):1815](http://www.efsa.europa.eu/en/efsajournal/doc/1815.pdf) | | Riboflavin (Vitamin B2) | | | | [EFSA Journal 2010;8(10):1814](http://www.efsa.europa.eu/en/efsajournal/doc/1814.pdf) | | Niacin (Vitamin B3) | | | | [EFSA Journal 2010;8(10):1757](http://www.efsa.europa.eu/en/efsajournal/doc/1757.pdf) | | Copper | | | | [EFSA Journal 2009;7(9):1211](http://www.efsa.europa.eu/en/efsajournal/doc/1211.pdf) | | Biotin | | | | [EFSA Journal 2010;8(10):1728](http://www.efsa.europa.eu/en/efsajournal/doc/1728.pdf) | * * * Sourcing At AVEA, we prioritise transparency and quality. We manufacture in Switzerland and source globally, focusing on ingredients with excellent bioavailability and high activity through standardised plant extracts. Every batch is rigorously double-tested for purity by an independent Swiss lab. We go beyond standard labelling to provide detailed information, and our customer service team is available for any questions or test result requests. | Active ingredients | Supplier | Production method | | --- | --- | --- | | Sodium Hyaluronate (Hyaluronic Acid) | Productos Químicos Gonmisol S.A. | Fermentation | | Moldavian Dragonhead Extract (DracoBelle™ Nu) | Mibelle AG | Dracocephalum moldavica extraction | | L-Ascorbic Acid (Vitamin C) | Shanghai Freemen Chemicals Co., Ltd | Fermentation | | Wheat Seed Extract (Ceramosides™) | Seppic S.A | Triticum aestivum extraction and acetone purification | | Nicotinamide (Niacin, Vitamin B3) | dsm-firmenich AG | Chemical synthesis | | PhytoCellTec™ Md Nu (Apple Fruit Cell Culture Biomass) | Mibelle AG | Fruit cell culture extract | | Beta Carotene (Source of Vitamin A) | Lycored Corp | Fermentation | | Riboflavin (Vitamin B2) | Natural Alternatives International, Inc. (NAI) - Hubei Guangji Pharmaceutical Co., Ltd. | Fermentation | | Cupric Gluconate (Copper) | ECSA Chemicals AG | Chemical synthesis | | D-Biotin (Biotin) | dsm-firmenich AG | Chemical synthesis | * * * Shipping We ship worldwide, free delivery above 50£/€/CHF, 5-10 days from dispatch depending on your region. ## SkinSpan™ Skin cell renewal Add to Cart ## Clean, transparent ingredients backed by science Formulated with traceable, clinically studied ingredients. Developed and manufactured in Switzerland. Third-party test results See full supplement facts ## Ceramosides™ 30 mg Concentrated gluten free phytoceramides extracted from wheat that help rebuild the skin’s natural lipid barrier, locking in moisture and protecting against external irritants. They improve skin smoothness, hydration, and elasticity – clinically shown to reduce fine lines and dryness. ## PhytoCellTec™ Md Nu 10 mg A patented plant stem cell extract derived from a rare Swiss apple variety. It