Knowledge Base

--- url: https://avea-life.com/pages/sereniser-science title: Unknown scraped_at: 2025-11-29 type: shopify --- Sereniser Science **The Sereniser** is formulated with clinically studied extracts like **Safr’Inside™, Holixer™, and Serezin™**, along with **L-theanine**, **Magnesium Bisglycinate**, and **Vitamin B6**. It’s designed to support the body’s natural sleep architecture by balancing cortisol, promoting GABA and serotonin activity, and restoring deep, uninterrupted rest – without sedation or dependency. The science of restorative sleep **How the Sereniser supports your body’s natural sleep rhythm** **SCIENCE-BACKED BOTANICALS & NUTRIENTS** **Clinically studied ingredients that support better sleep, naturally** ## Safr’Inside™ A standardised, patented, highly bioavailable saffron extract shown to improve sleep quality, reduce time to fall asleep, and ease anxious thoughts — all by supporting serotonin-melatonin conversion and cortisol balance. ## Holixer™ A clinically studied Holy Basil extract that helps regulate cortisol levels, reduce stress, and support parasympathetic nervous system activity — promoting calmer nights and deeper rest. ## Serezin™ A botanical duo of Ginger and Boswellia extracts designed to relieve nighttime discomfort and support restorative sleep. Clinically shown to improve sleep quality and make waking up easier. ## L-Theanine An amino acid found in green tea, known for promoting a calm state without sedation. L-theanine supports alpha brain waves — helping reduce mental overstimulation and ease into sleep, even after a hectic day. It’s also known to offset the jittery effects of caffeine, making it ideal for restoring calm in the evening. ## Magnesium Bisglycinate A highly bioavailable and gentle form of magnesium that helps relax muscles, calm the nervous system, and support deep sleep. Bisglycinate is bound to glycine — an amino acid that enhances absorption and has its own calming effect, making it especially effective for sleep without digestive discomfort. ## Vitamin B6 An essential cofactor for the production of GABA and serotonin — two key neurotransmitters involved in mood and sleep regulation. Vitamin B6 helps support a balanced circadian rhythm and contributes to better stress resilience and emotional stability. 1. Fall asleep faster ### Calm your nervous system and ease into rest Falling asleep isn’t just about feeling tired — it’s about creating the right internal conditions: calming brain activity, relaxing the body, and triggering your natural melatonin rhythm. The Sereniser supports this process by combining L-Theanine, which promotes alpha brain waves and reduces mental overstimulation, with magnesium bisglycinate to support GABA signalling and ease physical tension. Together with Safr’Inside™, a standardised saffron extract shown to support serotonin regulation, these compounds help your brain shift smoothly into a sleep-ready state — setting the stage for deep, natural rest. 2. Stay Asleep Longer ### Support deep, stable, uninterrupted sleep Many people don’t struggle to fall asleep — they struggle to stay asleep. Mid-night wakeups are often caused by cortisol spikes, restlessness, or dysregulated sleep rhythms. The Sereniser targets these pathways with Holixer™, a plant-based extract of holy basil that has been clinically shown to reduce perceived stress and help stabilise nighttime cortisol levels. Safr’Inside™ supports ongoing serotonin–melatonin balance, while Serezin™, a botanical complex of ginger and boswellia, helps reduce nighttime tension and physical discomfort — two subtle but powerful disruptors of continuous sleep. [Try Our Sereniser](https://avea-life.com/products/sereniser) 3. Wake Up Refreshed ### Feel mentally clear and physically recharged in the morning The goal isn’t just sleep — it’s sleep that restores. The Sereniser supports your body’s ability to complete full sleep cycles, including deep and REM phases, so you wake up feeling like yourself again. Its non-sedative formula avoids grogginess or dependency, while Serezin™ has been shown to improve ease of waking and morning clarity in clinical studies. Magnesium bisglycinate and vitamin B6 help maintain neurotransmitter balance overnight — supporting emotional calm and next-day resilience. [Try Our Sereniser](https://avea-life.com/products/sereniser) The smarter way to sleep ### Non-sedative. Non-habit forming. Truly restorative. Most sleep supplements override your system. The Sereniser supports it. By supporting key pathways like GABA, serotonin, and cortisol — without melatonin or sedation — it helps you fall asleep naturally, stay asleep longer, and wake up refreshed. No grogginess. No dependency. Just better sleep, night after night. [Try Our Sereniser](https://avea-life.com/products/sereniser) SCIENTIFIC EVIDENCE ## The science behind the benefits | Benefits | References | | --- | --- | | Reduces perceived stress and cortisol levels | [Lopresti et al., 2022](https://pubmed.ncbi.nlm.nih.gov/36185698 "https://pubmed.ncbi.nlm.nih.gov/36185698")<br>[Saxena et al., 2011](https://onlinelibrary.wiley.com/doi/10.1155/2012/894509 "https://onlinelibrary.wiley.com/doi/10.1155/2012/894509")<br>[Hidese et al., 2019](https://pmc.ncbi.nlm.nih.gov/articles/PMC6836118/ "https://pmc.ncbi.nlm.nih.gov/articles/PMC6836118/")<br>[Wang et al., 2022](https://www.sciencedirect.com/science/article/pii/S2213453021001324 "https://www.sciencedirect.com/science/article/pii/S2213453021001324")<br>[Pouchieu et al., 2023](https://pubmed.ncbi.nlm.nih.gov/37447245 "https://pubmed.ncbi.nlm.nih.gov/37447245") | | Improves sleep quality and duration | [Lemoine et al, 2019](https://pubmed.ncbi.nlm.nih.gov/31331545/)<br>[Breus et al., 2024](https://esmed.org/MRA/mra/article/view/5410/99193548123)<br>[Lian et al., 2022](https://www.sciencedirect.com/science/article/abs/pii/S1389945722000739)<br>[Kim et al., 2019](https://pmc.ncbi.nlm.nih.gov/articles/PMC6366437/) | | Supports melatonin rhythm via serotonin balance | [Jadidi et al, 2022](https://pmc.ncbi.nlm.nih.gov/articles/PMC9804944/)<br>[Field et al., 2022](https://pmc.ncbi.nlm.nih.gov/articles/PMC9787829/) | | Enhances sleep continuity and morning clarity | [Abbasi et al., 2012](https://pmc.ncbi.nlm.nih.gov/articles/PMC3703169/)<br>[Pachikian et al., 2021](https://pmc.ncbi.nlm.nih.gov/articles/PMC8145009/) | Ingredient safety profile | Ingredients | References | | --- | --- | | Safr’Inside™ (Saffron Extract) | [Jackson P.A., et al., 2021](https://pmc.ncbi.nlm.nih.gov/articles/PMC7882499/ "https://pmc.ncbi.nlm.nih.gov/articles/PMC7882499/")<br>[Noorbala A.A., et al., 2005](https://pubmed.ncbi.nlm.nih.gov/15707766/ "https://pubmed.ncbi.nlm.nih.gov/15707766/") | | Holixer™ (Holy Basil Extract) | [Lopresti A.L., et al., 2022](https://pubmed.ncbi.nlm.nih.gov/36185698/ "https://pubmed.ncbi.nlm.nih.gov/36185698/") | | Serezin™ (Ginger + Boswellia Extracts) | [PLT Health](https://www.plthealth.com/product-catalog/serezin "https://www.plthealth.com/product-catalog/serezin") | | L-Theanine (from Green Tea Extract) | [Lyon M.R., et al., 2011](https://pubmed.ncbi.nlm.nih.gov/22214254/ "https://pubmed.ncbi.nlm.nih.gov/22214254/") | | Magnesium Bisglycinate | [European Food Safety Authority](https://www.efsa.europa.eu/en/efsajournal/pub/718 "https://www.efsa.europa.eu/en/efsajournal/pub/718") | | Vitamin B6 (as Pyridoxal-5-Phosphate) | [European Food Safety Authority](https://efsa.onlinelibrary.wiley.com/doi/10.2903/j.efsa.2008.760 "https://efsa.onlinelibrary.wiley.com/doi/10.2903/j.efsa.2008.760") |