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--- url: https://avea-life.com/pages/nad-science title: Unknown scraped_at: 2025-11-29 type: shopify --- NAD+ SCIENCE ### NAD+ levels decrease with age NAD+ is a [crucial coenzyme](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7973386/#:~:text=NAD%2B%20regulates%20energy%20metabolism%2C%20DNA,gene%20expression%2C%20and%20stress%20response.&text=NAD%2B%20deterioration%20contributes%20to%20the,%2C%20cancers%2C%20and%20neurodegenerative%20diseases.) found in every cell, essential for energy metabolism, DNA repair, and gene expression. Higher NAD+ levels are linked to longevity and reduced age-related decline. However, with age or certain lifestyles, NAD+ naturally decreases, impacting vital cellular functions. [What is NAD+?](https://insights.avea-life.com/longevity/what-is-nmn-and-how-does-it-work/) NMN SCIENCE ### NMN is a potent NAD+ precursor [NMN](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238909/ "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238909/"), a vitamin B3 derivative, serves as a precursor, offering a promising approach to optimise NAD+ levels in your body. Avea's NMN supplement, featuring advanced [Longevir™ NMN](https://longevir.com/ "https://longevir.com/"), targets cellular ageing by boosting NAD+ levels, proven effective in clinical trials, with 99% purity. [LEARN MORE](https://avea-life.com/products/nmn) from your cells to your self Our NMN is a reliable, stable way to enhance NAD+, ensuring optimal bioavailability and longevity benefits. [Learn More](https://avea-life.com/products/nmn) ### THIRD-PARTY TESTED ### EXPERT FORMULATED ### 5 STAR REVIEWS ## optimal daily NAD+ booster [The Vitality Routine](https://avea-life.com/products/bundle) BESTSELLER BESTSELLER - [Vitality Bundle$135.00 ~~$141.00~~](https://avea-life.com/products/bundle "Vitality Bundle") Recent insights show that 250mg of NMN [optimises](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9158788/ "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9158788/") ageing pathways, as well as an [elevated NAD+ production](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861325/ "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861325/") occurs with synergistic NMN and active ingredients. The Avea Vitality Routine is our powerful duo with NMN and an elegant blend of antioxidants (400mg)—Resveratrol, Betaine, Apigenin, Pterostilbene, and CoQ10—sophisticatedly targeting multiple hallmarks of ageing simultaneously. [View Product](https://avea-life.com/products/bundle) SCIENTIFIC EVIDENCE | NMN Benefits | Scientific Evidence | | --- | --- | | DNA Repair | [Li,J et al., 2017](https://pubmed.ncbi.nlm.nih.gov/28336669/ "https://pubmed.ncbi.nlm.nih.gov/28336669/")<br>[Amano,H et al., 2019](https://pubmed.ncbi.nlm.nih.gov/30930169/ "https://pubmed.ncbi.nlm.nih.gov/30930169/") | | Metabolism | [Pencina KM et al., 2023](https://pubmed.ncbi.nlm.nih.gov/36740954/ "https://pubmed.ncbi.nlm.nih.gov/36740954/") [Yamane, T et al., 2023](https://pubmed.ncbi.nlm.nih.gov/37344088/ "https://pubmed.ncbi.nlm.nih.gov/37344088/") [Morita J et al., 2022](https://www.toukastress.jp/webj/article/2022/GS22-16.pdf "https://www.toukastress.jp/webj/article/2022/GS22-16.pdf") | | Ageing and longevity | [Niu, K. M et al., 2021](https://pubmed.ncbi.nlm.nih.gov/34912838/ "https://pubmed.ncbi.nlm.nih.gov/34912838/") [Mills, K. F et al., 2016](https://pubmed.ncbi.nlm.nih.gov/28068222/ "https://pubmed.ncbi.nlm.nih.gov/28068222/") [Fang, E.F et al., 2019](https://www.nature.com/articles/s41467-019-13172-8#citeas "https://www.nature.com/articles/s41467-019-13172-8#citeas") | | Neurological | [Li-Hui ru et al., 2023](https://www.sciencedirect.com/science/article/pii/S2213231723001465 "https://www.sciencedirect.com/science/article/pii/S2213231723001465") [Yu, M., Zheng et al., 2022](https://pubmed.ncbi.nlm.nih.gov/35769369/ "https://pubmed.ncbi.nlm.nih.gov/35769369/") | Ingredient safety profile | Ingredients | References | | --- | --- | | β-Nicotinamide Mononucleotide | [Fukamizu Y., et al., 2022](https://www.nature.com/articles/s41598-022-18272-y.epdf?sharing_token=IkwRcH4LSUQVeWVCP6DEvNRgN0jAjWel9jnR3ZoTv0O8-yVyLfd-eE-IRzvsrtxeiI6Uv3aNTAUTBZmpHw93r5XNzmFmaF3p3w-kb59NbZUY8XBoHkTy_TLKtPayuzlllRu7QcVC7kRbzyz64YxWjgPSnBu05GLHAIZDHsIq6Pc%3D)<br>[Song Q., et al., 2023](https://www.sciencedirect.com/science/article/pii/S2161831323013595)<br>[Okabe K. et al., 2022](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036060/) |